Scientist II/ Senior Scientist, Discovery Biology
DEPARTMENT: Discovery
REPORTING TO: Associate Director, Discovery Biology
LOCATION: Office space – San Francisco, Onsite Lab - South San Francisco, CA
FULL TIME
Job Summary:
Ouro Medicines is looking for a Scientist II/ Senior Scientist, Discovery Biology, to design and perform the necessary immunology-based assays to characterize the effect of pipeline antibody therapeutic candidates on immune cells.
Responsibilities:
- Act as an immunology subject matter expert on product teams in the candidate selection stage all the way to regulatory filing.
- Liaise with external CROs to interpret and troubleshoot outsourced experiments.
- Design multicolor flow cytometry panels to measure target antigen expression across immune cell subsets.
- Source and isolate PBMCs and T/B cells from donor blood.
- Design protocols to culture and differentiate immune cells of interest.
- Design and oversee in vivo efficacy and toxicology studies at third-party CROs.
- Design and perform co-culture assays of primary cells and antibody candidates to measure depletion of immune subsets.
- Design and perform cytokine release assays to compare antibody candidates.
Qualifications:
- PhD in Immunology or relevant subject (Molecular or Cell Biology).
- 2-4+ years of relevant immunology experience in the pharma/biotech industry or Postdoc.
- Background in B cell biology is a significant plus.
- Hands-on experience with immunophenotyping flow cytometry panels (8+ colors).
- Experience with cell culture of primary B/T cells and handling whole blood.
- Experience designing and overseeing in vivo experiments conducted at third-party CROs.
- Extensive experience with FlowJo and GraphPad Prism. Working knowledge of RT-PCR and RNA-seq data analysis and interpretation is a plus.
- Ability to generate, critique, and succinctly present data to leadership.
- Ability to troubleshoot experiments and lead the effort to overcome scientific obstacles.
- Self-starter who is proactive and finds ways to contribute in a fast-paced environment.
Pay Range & Benefits:
- The base salary range for this role is $108,200 - $178,400; The pay range provided is an estimated base range for this role. Exact compensation may vary based on skills, experience, and education.
- We offer an excellent benefits program, including Medical, Dental, and Vision plans, company-paid holidays, and more!
About Ouro Medicines:
Ouro Medicines is an early-stage biotherapeutic company located in San Francisco. Our purpose is to develop novel therapeutics that redefine the future for people with immune-mediated diseases. We have a growing pipeline of antibody-based therapeutics at different stages of research and development.
To Apply for this Role:
Please send an email with your resume and cover letter to careers@ouromeds.com.